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 RESEARCH PAPER
Year : 1992  |  Volume : 24  |  Issue : 2  |  Page : 111-113

To compare the efficacy of atenolol and acebutolol on isometric exercise - induced hemodynamic changes



Correspondence Address:
Lal Avtar


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: The efficacy of atenolol (single dose 50 mg and multiple doses 50 mg bid x 5 days) and acebutolol (single dose 200 mg and multiple doses 200 mg bid x 5 days), on Isometric excercise (IME) -induced changes in systolic blood pressure (SDP), diastolic blood pressure (DBP), heart rate (HH), HR-SBP product and maximum oxygen consumption (MV02) was studied in 6 healthy volunteers, in a controlled, randomized, double blind and cross over study. Atenolol in multiple doses caused significant lowering of IME- induced rise in SBP and DBP (P < 0.02 and P < 0.01 respectivelv). The single dose of acebutolol caused significant decrease in IME-induced increase in SBP and DBP (P < 0.01 and P < 0.05 respectively) and in multiple doses caused significant fall in IME-Induced DBP (P < 0.02). Atenolol caused significant decrease in IME-induced rise in HR, both by its' single and multiple doses (P < 0.0l), whereas acebutolol lowered it significantly only in single dose (P < 0.05). Comparison of reduction by atenolol and acebutolol on IME-induced hemodynamic changes reveals that atenolol is superior to acebutolol






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