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 RESEARCH PAPER
Year : 1991  |  Volume : 23  |  Issue : 2  |  Page : 95-98

Caffeine induced psychomotor behaviour in mice and its antagonism by some drugs



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K Gyawali


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1. The pscyhomotor effect of caffeine on mice was tested using the hole-board exploratory behaviour and the forced swimming test. 2. Caffeine produced a dose-dependent decrease in the exploratory behaviour and a decrease in the period of immobility respectively. 3. Nifedipine ( 1.5 mg/kg), dilazep (7.5 mg/kg) and verapamil (10 mg/kg) each antagonized the effect of caffeine (20 mg/kg) in either of the methods. 4. It can thus be concluded that effects of caffeine on psychomotor behaviour can be antagonised by either blocking calcium channels or by increasing adenosine levels at synapse.






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