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 RESEARCH PAPER
Year : 1991  |  Volume : 23  |  Issue : 2  |  Page : 81-85

Co-trimoxazole & co-trimazine : A comparative bioavailability study



Correspondence Address:
P Mahajan


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Source of Support: None, Conflict of Interest: None


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1. A cross over bioavailability study was carried out with co-ttimoxazole and co-trimazine administered in a dose of 2 tab. BD and 1 tab. BD respectively for 15 doses each, in normal healthy volunteers. 2 Plasma trimethoprim concentration was higher in the co-trimoxazole treated group as compared to the co-trimazine treated group (p<0.02). 3. Serum sulfamethoxazole concentrations were higher than serum sulfadiazine concentrations in the co-trimoxazole and co-trimazine treated groups respectively. 4. The time for reaching the peak and steady state concentrations of drugs in the two treatment groups did not differ significantly for comparable drugs.






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