IPSIndian Journal of Pharmacology
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Year : 1991  |  Volume : 23  |  Issue : 2  |  Page : 117-120

A comparison of “in-vitro” hemolytic effect of some drugs and their interaction with some stabilizers



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1. In vitro hemolytic effect of phenol and vit A alcohol and its esters were studied on cat, rabbit and human washed RBC suspended in isotonic saline on a comparative basis. 2. Simultaneously, time and temperature dependance study and stabilizing effect of some steroids and (-tocopheryl acetate on drug induced hemolysis were investigated. 3. Vit A alcohol was the most potent hemolytic agent among the vit A preparations. With this drug hemolysis occured even at a low temperature (20ø C). 4. While cholesterol showed no inhibition of drug induced hemolysis, (-tocopheryl acetate was the most effective stabilizer.






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