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 RESEARCH PAPER
Year : 1991  |  Volume : 23  |  Issue : 2  |  Page : 104-108

Effect of experimental diabetes on adrenergic receptor activity in cardiac and non-cardiac smooth muscles of rat



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D P Joshi


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1. The effect of streptoxotocin-induced diabetes on adrenergic receptor activity was studied in cardiac, vascular and non-vascular smooth muscles of rat. 2. Diabetic rats showed weight loss, hyperglycemia and bradycardia. There was a reduction in weight of heart and aortic strips, but not in that of vas deferens and anococcygeus muscles. 3. Hearts from diabetic rats showed subsensitivity whereas aortic strips showed supersensitivity to noradrenaline (NA). However, vas deferens and anococcygeus did not show any change in responses to NA. 4. In experimental diabetes, changes in adrenergic receptor activity is specific to cardiac and vascular smooth muscles only.






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