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 RESEARCH PAPER
Year : 1987  |  Volume : 19  |  Issue : 3  |  Page : 192-199

Comparative bioavailability, pharmacokinetics and dosage regimen of three different brands of oxytetracycline in dairy cows after intramuscular administration


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M K Singh


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1. Comparative bioavailability, pharmacokinetics and dosage regimen of three different commercial preparations of oxytetracyclime (Preparations X & Z-oxytetracycline hydrochloride; Preparation Y-oxytetracycline dihydrate) equivalent 0.5 mg/kg of base were studied post i. m. injection of the drugs in dairy cows. 2. Preparations Y and Z maintained a significantly low plasma concentration between 0.5 to 1 h and 2 to 8 respectively, as compared to preparation X. 3. No significant difference was observed for the drug concentration in milk among these preparations. 4. Kinetic parameters such as extrapolated zero time concentration during elimination phase (B), area under curve of plasma (AUC) were significantly lower while volume distribution (VdB ) and total body clearance (ClB ) were observed to he significantly higher for preparation Z as compared to preparation X. 5. There was no significant difference between the kinetic parameters of preparation X versus Y and Y versus Z. 6. The calculated dosage regimen of these preparations showed a significantly higher loading dose (D*) for preparation Z at the dosage interval of 12 h for maintaining C(pmin (MIC) of 0.5, 1.0 and 1.5(g/ml as compared to preparation X only.






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