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 RESEARCH PAPER
Year : 1986  |  Volume : 18  |  Issue : 1  |  Page : 1-8

Role of nervous system in experimental myocardial ischaemia in dogs



Correspondence Address:
D N Das


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1. Coronary ligatjon (CL) in dogs produced ventricular fibrillation (VF) in 80% animals, myocardial glycogenolysis and increased cholinesterase (ChE) activity of myocardium and blood. 2. Pretreatment with morphine sulphate significantly reduced the incidence of CL-induced VF and prevented the biochemical changes induced by ischaemia. 3. Pretreatment with atropine methiodide or bilateral vagotomy failed to affect the incidence of CL-induced VF significantly, but increased the ischaemiai-induced depletion of the ventricular myocardial glycogen content. 4. The results indicated that neither genesis nor prevention of VF followi'ng myocardial ischaemia (MI) were related to the haemodynamic and biochemical changes in the myocardium. 5. The anti-arrhythmic activity of narcotic analgesics are probably due to their central actions. 6. The central nervous system and the adrenergic system seem to play important role in the genesis of post-ischaemic arrhythmias, while the cholinergic system appears to have a cardio-protective action.






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