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 RESEARCH PAPER
Year : 1985  |  Volume : 17  |  Issue : 4  |  Page : 224-228

Effect of nonsteroidal anti-inflammatory drugs on (NSAIDS) on diuretic property of hydorchlorthiarzide



Correspondence Address:
G F Shah


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1. Effects of nonsteroidal anti-inflammatory drugs (NSAIDS) on hydrochlorothiazide (HT) induced urine volume, urinary sodium, potassium and creatinine excretion were examined in conscious rats. 2. The diuretic activity, and the increased urinary sodium and potassium excretion elicited by HT (2.5 and 5 mg/kg) were inhibited after oral administration of NSAlDS like indomethacin (ID), oxyphenbutazone (OPB), ibuprofen (IBF) and naproxen (NAP), in doses which inhibited the rat carrageenin induced hind paw oedema. 3. Ibuprofen was most Potent and Naproxen was least Poent in antagonising both diuretic and Natriuretic activity.






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