IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1985  |  Volume : 17  |  Issue : 4  |  Page : 205-209

Effect of lowering bath temperature on the sensitivity of the rat isolated vas deferens to noradrenaline



Correspondence Address:
J S Pasnani


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1. Effect of change in bath temperature on the responses to various agonists (NA, KCl, and methoxamine) were investigated in rat isolated vas deferens in the presence of various blockers. 2. Reducing the bath temperature from 37C to 24C potentiated (P<0.05) the responses to exogenously added NA and KC1 while depressed (P<0.05) those to methoxamine. 3. Cocaine potentiated (p<0.05) the responses to NA more at 37C than at 24 C bath temperature. 4. Normetanephrine and nialamide potentiated the responses to higher concentrations of NA at 37C, at 24C their effects were variable. 5. Pyrogallol had no effect on the responses to NA at 37C and 24C. 6. The results suggest that the effects of cooling on the responses to NA may be due to summation of its many effects namely inhibition of metabolising enzymes (MAO and COMT) and blockade of uptake mechanisms.






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