| RESEARCH PAPER
|Year : 1985 | Volume
| Issue : 4 | Page : 192-196
Cardiovascular effects of central and peripheral administration of dopamine in hypertensive and normotensive rats
JSL Mok, ML Kong, JS Hutchinson
1. Effects of intracerebroventricular (i.c.v.) and intravenous (i.v.) injection of dopamine (DA), 12.5- 400 (g/kg on blood pressure (BP) and heart rate (HR) were studied in conscious spontaneously hypertensive rats (SHR) and compared with 2 other models of hypertension and their normotensive controls.
2. Blood pressure decreased significantly in SHR after i.c.v. DA when compared to hypertensive and normotensive controls in a dose-related manner.
3. HR decreased in all cases except that at a dose of more than 25(gDA/kg in SHR an increase was seen.
4. The results support the hypothesis for a central dopaminergic insufficiency in SHR.
Source of Support: None, Conflict of Interest: None