| RESEARCH PAPER
|Year : 1985 | Volume
| Issue : 3 | Page : 144-147
Serum and cerebrospinal fluid levels of phenytoin in epileptic patients in relation to control of seizures
NF Jaffery, GK Ahuja, BL Jailkhani
1. In 33 epileptic patients on phenytoin monotherapy. the CSF levels of the drug constituted 12.5( 5% (range 5.4 to 23%) of the serum levels.
2. The mean serum levels of the drug (13.356 (g/ml) in controlled patients (17) were not significantly different from the levels in uncontrolled patients (11). The mean CSF levels in uncontrolled patients (0.92(O.32) were significantly lower (p<0.001) than those in controlled patients (1.49(0.59).
3. In 5 patients who developed toxicity, the serum (27.3 ( 10.6) as well CSF (5.3 ( 1.8) levels of phenytoin were significantly higher than those of uncontrolled and controlled (without toxicity) patients.
N F Jaffery
Source of Support: None, Conflict of Interest: None