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 RESEARCH PAPER
Year : 1985  |  Volume : 17  |  Issue : 2  |  Page : 108-112

Behavioural evidence for direct stimulation of rat brain 5-Hydroxytryptamine receptors by ergometrine



Correspondence Address:
T R Bapat


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1. Ergometrine produced a behavioural syndrome in the rat which was characterized by head and body shakes, lateral head weaving, forepaw treading, hindlimb abduction and Straub tail. 2. Pretreatment with 5-HT receptor antagonists, cyproheptadine and methysergide, significantly decreased the intensity of the behavioural syndrome produced by ergometrine. 3. Pretreatment with p-chlorophenylalanine and clomipramine significantly decreased the intensity of the behavioural syndromes induced by fenfluramine and p-chloramphetamine but had no significant effect on the intensity of the behavioural syndrome produced by ergometrine. 4. The results indicate that ergometrine produces the 5-HT mediated behavioural syndrome by directly stimulating the central 5-HT receptors.






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