IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 258 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1294    
    Printed85    
    Emailed0    
    PDF Downloaded86    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1985  |  Volume : 17  |  Issue : 2  |  Page : 103-107

Effect of antiarrhythmic drugs on ventricular fibrillation threshold and cardiac stores of norepinephrine in the cat.



Correspondence Address:
M Pande


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

1. Comparative evaluation of the effect of anti-arrhythmic drugs on ventricular fibrillation threshold (VFT) and on theconcentration of norepinephrine (NE) in the different parts of the myocardium of the cat has been undertaken. 2. In pentobarbitone anaesthetised cats fibrillation induced by electrical stimulation (ES.) of the left ventricle caused reduction of NE in the heart. 3. Quinidine and disopyramide, the membrane stabilizers; lidocaine, a local anaesthetic; adrenergic receptor blockers like phenoxybenzamineand propranoloI, and verapamil, a calcium antagonist, caused bradycardia, hypotension and decrease in NE content. 4. Pretreatment with quinidine, disopyramideand lidocaine inhibited further release of NE from the myocardium following E.S. and significantly raised VFT. 5. Phenoxybenzamine (10 mg/kg), propranolol (5 mg/kg) and verapamil (1 mg/kg) did not inhibit the release of NE. Phenoxybenzamine provided protection against ventricular fibrillation whereas propranolol and verapamil failed. 6. The results suggest the involvement of ( adrenergic receptor as a contributing factor in the onset of ventricular fibrillation induced by E.S.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow