| RESEARCH PAPER
|Year : 1984 | Volume
| Issue : 4 | Page : 228-230
Pharmacokinetic study of penicillin G and ampicillin in buffalo calves
MK Singh, C Jayachandran, NC Banerjee
I. Plasma concentrations of pencillin G (10,000 iu/kg.) and Ampicillin (6 mg/kg.) (administered intramuscularly) in six buffalo calves were estimated at different time intervals by microbiological.assay.
2. Penicillin G attained a peak concentration of 9.53 ( 1.46 iu/ml. at 15 min. and the therapeutic concentration (Cpther) was maintained for about 5 hr. -3.
3.On the other hand, ampicillin attained its peak concentration of 8.50 ( 1.28 (g/ml at 1 hr and its Cpther, was maintained for about 8 hr.
4. The elimination half-life( t1/2 B) was found to be 1.10 ( 0.20 hr and 1.35 ( 0.32 hr for penicillin G and ampicillin respectively.
M K Singh
Source of Support: None, Conflict of Interest: None