| RESEARCH PAPER
|Year : 1984 | Volume
| Issue : 4 | Page : 225-227
Pharmacokinetics of dapsone in presence of dipyrone in leprosy patients
DR Krishna, Rao AVN Appa, TV Ramanakar, MC Prabhakar
1 Different pharmacokinetic parameters of dapsone were studied, following oral administration of dapsone (100 mg.) alone or in combination with dipyrone(1000 mg.) in six untreated patients of leprosy, over a period of 8 hours.
2. The mean blood levels, the mean serum half-life and the mean AUC O-8 hrs of dapsone were reduced in the presence of dipyrone.
3. The cumulative urinary excretion of dapsone was increased following the administration of dapsone and dipyrone in combination.
D R Krishna
Source of Support: None, Conflict of Interest: None