IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1984  |  Volume : 16  |  Issue : 3  |  Page : 158-161

Effect of alloxan on some parameters of lenticular pathway in rat glutathione and glutathione reductase



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U M Rawal


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1. The effect of alloxan, a sugar cataractogenic substance on glutathione (GSH) and glutathione reductase (GSH-R) activity in blood, aqueous humor and lenses of normal and treated rats is reported. 2.In contrast to normal lenses, alloxan induced cataractous lenses showed an i ncrease in CSH-R activity and fall in CSH content in blood, aqueous humor and Iens indicating that alloxan may interfere with intracellular oxidation reduction process in the lens and thus lead to cataract formation.






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