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 SHORT COMMUNICATION
Year : 1984  |  Volume : 16  |  Issue : 2  |  Page : 112-114

Yohimbine prolongs the duration of antinociceptive activity of morphine in mice



Correspondence Address:
A M Ageel


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1. The effect of intraperitoneal yohimbine on pain threshold in mice has been investigated. The drug was devoid of any analgesic activity at lower doses (1 mg/kg). However, the pain reactions was modified at 10 mg/kg. 2. Subanalgesic doses of yohimbine prolonged the duration of morphine analgesia. 3. Alteration in the ratio of brain 5 HT : Noradrenaline has been proposed as a possible mechanism for the effects of yohimbine.






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