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 SHORT COMMUNICATION
Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 367-370

Cholinesterase activity of ranitidine: in vitro and in vivo studies



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T P Gandhi


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The effect of ranitidine was investigated on the contractile responses of frog rectus abdominis muscle to acetylcholine (Ach) and carbachol. Ranitidine was found to cause (a) potentiation of Ach responses but not that of carbachol, and (b) reversal of gallamine induced blockade of Ach contraction but not that of carbachol. Ranitidine was found to weakly inhibit the serum cholinesterases in-vim? The enzyme inhibition activity of ranitidine was very weak as compared to that of physostigmine.






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