| SHORT COMMUNICATION
|Year : 1983 | Volume
| Issue : 4 | Page : 361-366
Morphine dependence and withdrawal in rat: role of dopamine
ZY Khan, PC Dandiya
Dependence was induced in rats by repeated intraperitoneal injections of morphine sulfate withdrawal signs were precipitated by subcutaneous injection of naloxone. The dopamine agonists, i.e, apomorghine d-amphetamine and I-dopa aggravated the withdrawal signs while synthesis inhibitors / depletors of dopamine, i.e, reserpine and DL-a-methyl-p-tyrosine prevented the occurrence of almost all the withdrawal signs. These findings suggest the involvement of dopamine in the production of morphine dependence and withdrawal.
Z Y Khan
Source of Support: None, Conflict of Interest: None