IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 968 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1399    
    Printed88    
    Emailed0    
    PDF Downloaded85    
    Comments [Add]    

Recommend this journal

 

 SHORT COMMUNICATION
Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 361-366

Morphine dependence and withdrawal in rat: role of dopamine



Correspondence Address:
Z Y Khan


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Dependence was induced in rats by repeated intraperitoneal injections of morphine sulfate withdrawal signs were precipitated by subcutaneous injection of naloxone. The dopamine agonists, i.e, apomorghine d-amphetamine and I-dopa aggravated the withdrawal signs while synthesis inhibitors / depletors of dopamine, i.e, reserpine and DL-a-methyl-p-tyrosine prevented the occurrence of almost all the withdrawal signs. These findings suggest the involvement of dopamine in the production of morphine dependence and withdrawal.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow