IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 321-330

Studies on interactions of calcium antagonists with cardiotonic agents



Correspondence Address:
D K Basu


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Source of Support: None, Conflict of Interest: None


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Two calcium antagonists, viz., D-600 (a methoxy derivative of verapamil) and Nisoldipine, were tested for their influence on cardiac activity of frog heart in situ and rabbit atria. The interaction of these agents with the cardiotonic effects produced by the catecholamines, cardiac glycoside and free fatty acid (FFA), was also observed. Both the calcium antagonists exerted a negative cardiotropic effect on heart. They could affectively block the positive chronotropic effect, but not the inotropic effect of the catecholamines, both the positive chronotropic and inotropic effects of free fatty acids, but did not affect in any way the cardiotropic effect of digoxin.






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