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 RESEARCH PAPER
Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 313-320

Absorption kinetics of a new sulphonamide and trimethoprim combination



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S D Seth


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Blood levels of sulphadimidine (SDM) and Trimethoprim (TMP) combination have been studied in normal healthy volunteers. On the first day a single oral dose (SDM) 800 mg + TMP 160 mg) was given while on the second and third day the drug was administered twelve hourly. On an average the peak concentration of TMP in blood was obtained at 4th hour (2.66 'g/ml) and that of SDM by the 2nd hour (free 24.75 'g/ml, total 43.31 'g/ml). After multiple dosing on an average the increase in blood concentration at 48 and 72 hours was nearly 1.14 times for TMP and 1.53 and 1.51 times for free and total SDM respectively. The average blood ratio of SDM over TMP was maintained between 14 and 21 and indicates good distribution of SDM in the body.






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