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 RESEARCH PAPER
Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 293-302

Teratogenicity of monocrotophos in rats and rabbits



Correspondence Address:
A Janardhan


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Three dosage levels of Monocrotophos, an organophosphorous pesticide, were selected for teratogenicity studies. Four groups of rats, each consisting of twenty pregnant rats, were dosed orally with 0.0 (control) 1. 2, 1.8 and 2.4 mg/kg/day from day 6 to I5 of pregnancy. In another series, same dose levels of the test drug were administered to four groups of rabbits each consisting of four pregnant rabbits, through 6th to 18th day of gestation. Monocrotophos had no dysmorphogenic effect on the fetuses in both the species. It could affect adversely by reducing fetal weight and mean litter weight of the pups at birth. Decrease in maternal whoie blood cholinesterase activity was noticed in a dose related manner. The weight of live pups at the time of weaning was also reduced significantly due to the pesticide with a concomitant decrease in the number of live fetuses. The reduction in the mean weight of fetuses and the new borns and the growth retardation at the time of weaning in the treated groups is an indication of embryotoxicity of the pestiade.






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