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 RESEARCH PAPER
Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 269-277

Toxic effects of high dose oral administration of trimethoprim on some blood and hepatic parameters



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Effect of oral administration of trimethoprim (TMP) in high doses on body wheight, blood biochemical parameter and hepatic functions were studied in albino rats. High doses of TMP caused anaemia and growth retardation of the experimental animals. Total lipid and cholesterol content of serum increased while protein and phospholipid content of serum was reduced following TMP. Administration of trimethoprim, in doses of 50 mg and 100 mg/kg/day for 3 weeks produced deleterious effect on liver as a result of which total lipid and cholesterol contents of liver and its microsomal fraction increased significantly with elevated aminotransferase activities, Protein, phospholipid and RNA contents of liver and liver microsomes were reduced in the drug treated animals, while alkaline phosphatase activity of serum and liver remained unchanged. Liverweight/body weight ratio of the treated animals was also decreased as compared to that of controls. Administratien of this drug in 50 mg and 100 mg/kg/day for 2 weeks showed the change of all that parameters and enzymes in a similar pattern but of lesser intensity. Alteration in the concentration of the above parameters and enzymes of serum and liver may be correlated to intracellular liver injury.






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