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 RESEARCH PAPER
Year : 1983  |  Volume : 15  |  Issue : 3  |  Page : 189-195

Chlorpromazine induced inhibition of pinnal reflex in mice: involvement of central dopaminergic system



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P P Singh


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Chlorpromazine (CPZ) inhibited the pinnal reflex in mice in a dose dependent manner. Studies were conducted using agents influencing adrenegric and dopaminergic systems in order to study the mechanism of action. Reserpine, alpha-methyl-p-tyrosine, 6-hydroxydopamine and yohimbine blocked the inhibition of pinnal reflex induced by CPZ. None of the interacting agents had any per se effect on the pinnal reflex. Phenoxy-benzamine, phentolamine and propranolol did not alter the CPZ induced inhibition of pinnal reflex. Imipramine, a rettptake blocker of noradrenaline, did not potentiate the effect of the sub-minimal dose of CPZ. However, sub minimal effect of CPZ on pinnal reflex was potentiated by diethyldithiocarbamate and also by a higher but not by a lower dose of apomorphine. Haloperidol blocked the CPZ induced inhibition of the pinnal reflex. The results suggest that the chlorpromazine-induced inhibition of the pinnal reflex is central in origin and mediated by dopamine at the postsynaptic dopaminergic receptors.






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