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Year : 1983  |  Volume : 15  |  Issue : 3  |  Page : 165-170

Effect of L-Dopa, amantadine and tremorine on brain monamines

Correspondence Address:
S D Seth

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Source of Support: None, Conflict of Interest: None

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The effect of L-dopa, alone and in combination, on brain dopamine, norepinephrine, serotonin, 5-hydroxyindole acetic acid and monoamine oxidase activity was investigated in tremorine induced tremor syndrome in rats. L-dopa, alone and in combination with amantadine, produced a remarkable rise in dopamine and 5-hydroxyindole acetic acid and a reduction in serotonin content.Tremorine failed to influence any of the parameters. The findings suggest that L-dopa and amantadine have pro-found effects on brain biogenic amines which may account for the therapeutic effects as well as behavioural side-effects frequently encountered in clinical practice.


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