IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1066 
Small font sizeDefault font sizeIncrease font size
Navigate Here
    Next article
    Previous article
    Table of Contents

Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1452    
    Printed85    
    Emailed0    
    PDF Downloaded86    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1983  |  Volume : 15  |  Issue : 3  |  Page : 165-170

Effect of L-Dopa, amantadine and tremorine on brain monamines



Correspondence Address:
S D Seth


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

The effect of L-dopa, alone and in combination, on brain dopamine, norepinephrine, serotonin, 5-hydroxyindole acetic acid and monoamine oxidase activity was investigated in tremorine induced tremor syndrome in rats. L-dopa, alone and in combination with amantadine, produced a remarkable rise in dopamine and 5-hydroxyindole acetic acid and a reduction in serotonin content.Tremorine failed to influence any of the parameters. The findings suggest that L-dopa and amantadine have pro-found effects on brain biogenic amines which may account for the therapeutic effects as well as behavioural side-effects frequently encountered in clinical practice.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow