IPSIndian Journal of Pharmacology
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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 289-292

Distribution of chloramphenicol in blood and milk after oral administration in goat

Correspondence Address:
B K Roy

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In goats, single dose oral administration of chloramphenicol did not produce therapeutic blood levels of the drug at 25mg and 50 mg/kg bw but at 100 mg and 200 mg/kg it produced therapeutic antimicrobial levels for 24 h and for more than 24 h, respectively. Single oral dose at 100 mg and 200 mg/kg gave therapeutic milk levels for 3 to 24 h and 1 h to 48 h, respectively. Both blood and milk were free from the drug at 72 h post administration after 100 and 200 mg/kg single oral doses. Species difference with regard to drug adsorptions from G. I. tract has been Suggested.


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