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 RESEARCH PAPER
Year : 1982  |  Volume : 14  |  Issue : 3  |  Page : 263-267

Effect of restraint stress on haloperidol catalepsy in rats



Correspondence Address:
S K Bhattacharya


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The effect of restraint stress (1, 2 and 4 h) on haloperidol-induced catalepsy, was investigated in rats. Restraint stress produced a time-related potentiation of haloperidol catalepsy. This stress (4h)-induced potentiation of haloperidol catalepsy was attenuated after pretreatment with drugs known to decrease central serotonergic activity, prostaglandin synthesis inhibitors but not by metyrapone, an inhibitor of endogenous corticoid synthesis. The results suggest the involvement of serotonin and prostaglandinsin restraint stress haloperidol interaction. The results have been discussed in the context of earlier investigations reported from this laboratory, indicating- enhancement of rat brain serotonergic and prostagtandin activity, following restraint stress, and serotonergic mediation in prostaglandin effects. It is possible that restraint stress first enhances rat brain prostaglandin activity, which has been proposed as the first mediator of stress. Prostaglandins, in turn, activate the serotonergic system, in this species.






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