| RESEARCH PAPER
|Year : 1982 | Volume
| Issue : 2 | Page : 163-168
Kinetics of lithium in normal volunteers
CB Khare, A Sankaranarayanan, SK Khandelwal, KS Raghvan, R Srinivasamurthy
Six normal volunteers completed the study following oral administration of conventional and later slow release preparation of lithium carbonate. Mean serum levels over 24 h were calculated. The average time required to reach maximum concentration in serum was 5 h in conventional form and 6 h in case of slow release form. The maximum concentration did not differ significantly. The bio-availability of the conventional form was 79.9% of the slow release form. The volume of distribution and metabolic clearance rates for both the forms were similar. Implications of these findings are discussed.
C B Khare
Source of Support: None, Conflict of Interest: None