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 RESEARCH PAPER
Year : 1982  |  Volume : 14  |  Issue : 2  |  Page : 159-162

Anti-histaminic activity of a mannich base b-dimethyl aminoethyl p-chlorophenyl ketone HCl



Correspondence Address:
S C Chaturvedi


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(-dimethylamino ethyl p-chloro phenyl ketone hydrochloride, a para substituted acetophenone Mannich base showed marked antihiitaminic (Hz) activity in various in vivo and in vitro test models. It selectively antagonised the histamine incuded vasodepressor activity in anaesthetised cat, broncho -constriction in guinea - pig and spasm of guinea-pig ileum in a dose dependent manner. The compound failed to inhibit the H2-receptor Mediated positive chronotropic, but could completely abolish the positive inotropy on the isolated guinea - pig atrium. The compound was however found to be less potent than diphenhydramine.






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