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 RESEARCH PAPER
Year : 1982  |  Volume : 14  |  Issue : 2  |  Page : 143-148

The effect of adrenoceptor blockers (propranolol and phenoxybenzamine) on single – trial passive avoidance response in rats



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N Jagdev


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Rats received a single training trial on a n inhibitory avoidance (passive avoidance) rats, and retention trials 24 h (R-I) and 48 h (R-II) later.The animals were subjected to 5 different trial, scheduld(s) : control, pre-trial, pre-trial plus pre-retention, pre-retention, and post-trial in a special two chambered apparatus, and the step-through latency was determined. Propranolol (6.5 mg/kg ip) increased the mean 'step-through latencies significantly in groups III & IV (P < 0.05 and group II & V (P<0.001) as compared to that in group I on R-I There was a similar increase in the retest lalatencies in groups II & III (P<0.01) and group IV & V(p <0.001), as compared to that is group I on R-II. Phenoxybenzamine (5.0 mg/kg ip) had an insignificant effect on the retest latenoes in all the groups both after 24 h and 48 h retention trials.






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