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 RESEARCH PAPER
Year : 1981  |  Volume : 13  |  Issue : 4  |  Page : 341-347

Effects of phenformin and PGE2 on blood sugar, blood pressure and gastric acidity on Intravenous and intracerebroventricular administration in cats



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R S Diniz


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The effects of phenformin and PGE, were studied on blood sugar, blood pressure and gastric acidity in cats when administered by intravenous and intracerebroventricular routes. PGE, reduced the blood pressure,blood sugar level and gastric acidity on intravenous administra-tion, while phenformin increased the blood pressure and blood sugar level but reduced gastric acidity. On intracerebroventricular administraion PGE, increased the blood pressure and blood sugar level but reduced the gastric acid while the action of phenformin on these parameters is diagnally opposite. It is suggested that the action of phenformin on the above parameters, may be due to inhibition of prostaglandin synthesis.






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