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Year : 1981  |  Volume : 13  |  Issue : 4  |  Page : 317-324

Central - adrenergic mechanism of catecholamine induced hypothermia in guinea pigs

Correspondence Address:
R A Khan

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Source of Support: None, Conflict of Interest: None

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Intracerebroventricular administration of adrenaline, nor-adrenaline and phenylephrine through a chronically implanted cannula produced a fall followed by an after-rise in body temperature in guinea-pigs. Pretreatment with a-receptor antagonist tolazoline or phenoxybenzamine significantly reduced the hypothermia. Isoprenaline neither produced a significant fall in body temperature nor its slight hypothermic effect was blocked by propranolol. An involvement of central a-adrenoceptors in the production of catecholamine hypothermia in guinea-pig is suggested. The after-rise in temperature appears to be an unspecific fever.


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