| RESEARCH PAPER
|Year : 1981 | Volume
| Issue : 4 | Page : 317-324
Central µ - adrenergic mechanism of catecholamine induced hypothermia in guinea pigs
RA Khan, KP Gupta
Intracerebroventricular administration of adrenaline, nor-adrenaline and phenylephrine through a chronically implanted cannula produced a fall followed by an after-rise in body temperature in guinea-pigs. Pretreatment with a-receptor antagonist tolazoline or phenoxybenzamine significantly reduced the hypothermia. Isoprenaline neither produced a significant fall in body temperature nor its slight hypothermic effect was blocked by propranolol. An involvement of central a-adrenoceptors in the production of catecholamine hypothermia in guinea-pig is suggested. The after-rise in temperature appears to be an unspecific fever.
R A Khan
Source of Support: None, Conflict of Interest: None