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 RESEARCH PAPER
Year : 1981  |  Volume : 13  |  Issue : 4  |  Page : 313-316

Effect of minor tranquilizers on continuous acid gastric secretion in rats



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V G Oke


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The effect of various minor tranquilisers, viz., diazepam, chlordia-zepoxide and meprobamate on the gastric acidity, was studied by continuous recording of acid gastric secretionin rats. All the drugs caused a statistically significant fall in the gastric pH. Atropine had a partial protective effect whereas chlorpheni- ramine alone or in combination with atropine had no effect on the fall in gastric pH caused by diazepam. Cimetidine completely blocked the action of diazepam on the gastric pH. Thus, the action of diazepam causing a fall in gastric pH of rats appears to be predominantly mediated through a histaminergic (H2-receptor mediated) machanism.






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