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 RESEARCH PAPER
Year : 1981  |  Volume : 13  |  Issue : 4  |  Page : 293-300

Studies on the chronic toxicity and anticholinesterase activity of O, O-dimethyl-O-(3-Methyl -4- Nitrophenyl) Phosphorothioate (Sumithion) in rats



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The effect of Sumithion an organophosphorus insecticide on growth rate, various internal organs, and cholinesterase enzyme activity has been studied in growing male rats at dietary levels of 200 and 500ppm for 80 days.There was a mortality of 46.6% (7/15) in the group on 500 ppm during the first three weeks and all the animals in this group exhibited cholinergic symptoms in the second and third week of feeding. The surviving animals were found to be normal. No such adverse effect was observed in the group maintained on 200 ppm Sumithion diet. Al. though the weekly growth rate was linear in both the groups, it was significantly depressed in 500 ppm dosed group but not in the group on 200 ppm diet. Cholinesterase enzyme activity was inhibited by 97% in the surviving animals maintained on 500 ppm. Sumithion diet, while the inhibition was 60% in the group on 200 ppm. Organ weights of liver, heart, lung, brain, kidney, adrenals, seminal vesicles and prostate in the experimental group were not significantly different from the control group and no gross pathological changes were observed.






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