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 SHORT COMMUNICATION
Year : 1981  |  Volume : 13  |  Issue : 2  |  Page : 207-210

Interaction of anti-inflammatory agents with glibenclamide in rabbit



Correspondence Address:
V V Sharma


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The anti-inflammatory agents like. aspirin, phenylbutazone, indomethacin and ibuprofen were studied for drug interaction with glybenclamide in rabbits. All the agents studied excepting indomethacin interfered with glybenclamide induced hypoglycaemia. These drugs also affected carbohydrate metabolism per se as aspirin (40 mg/kg) produced hypoglycaemia and ibuprofen (10 mg/kg) hyperglycaemia. Pheaylbutazone (75 mg/kg) and aspirin (40 mg/kg) potentiated the glybenclamide induced hypoglycaemia.






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