IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1372 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1001    
    Printed68    
    Emailed0    
    PDF Downloaded61    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1981  |  Volume : 13  |  Issue : 2  |  Page : 137-145

Disposition of norepinephrine in the isolated caecorectum preparation of chick



Correspondence Address:
RCP Singh


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

. Disposition of (-) notepinephrine (NE) in the isolated caecorectal preparation of chick was studiedby recording cumulative dose response curves with (-) NE alone and in the presence of specific inhibitor of the mechanisms of amine inactivation and by using oil immersion technique. Relaxant effect of NE (10-5M) on caecorectum of chick contracted with carbachol was potentiated by about 43% with cocaine (3x 10-5M), 23% with iproniazid (10-4M) and 17% with tropolone (10-4M). The results of oil immersion technique indicated that "t50" was increased almost similarly after inhibition of uptake process, monoamine oxidase (MAO) or catechol-O methyl transferase (COMT). The results suggest that neuronal uptake was as important as the role payed by both COMT and MAO taken together.This is in contrast to that reported in mammalian tissues where the uptake process contributes mainly in the disposition of NE.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow