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 SHORT COMMUNICATION
Year : 1980  |  Volume : 12  |  Issue : 3  |  Page : 201-204

Comparative effects of gossypin and phenylbutazone on the temporal characteristics of carrageenin induced paw oedema and increased vascular permeability in rat



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N S Parmar


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. The effect of gossypin in comparison with phenylbutazone has been studied on the quantitative temporal characteristics of carrageenin induced rat paw oedema and protein extravasation. Both parameters showed a biphasic response with identical time courses, indicating that the protein extravasation took place throughout the reaction and that it was proportional to the severity of paw swelling. Gossypin significantly reduced initial as well as late phases of paw oedema and protein extravasation, while phenylbutazone failed to reduce the initial increase of vascular permeability in response to carrageenin. Possible difference in the mechanism of action of gossypin and phenylbutazone and the role of mediators involved in the inflammatory process have been discussed






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