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 RESEARCH PAPER
Year : 1980  |  Volume : 12  |  Issue : 3  |  Page : 173-180

Monitored release trials – A case study with ibuprofen



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P K Pispati


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. Histamine, 2-(2-pyridyl) ethylamine (PEA), a specific H, receptor agonist and 4-methyl-histamine (4-MH). A specific H2- receptor agonist all produced dose dependent contraction of uterine strips obtained from estrogen primed guineapigs. Mepyramine, a specific H1 receptor antagonist inhibited responses to histamine and PEA. Metiamide, a specific H2- receptor antagonist inhibited responses to histamine and 4-MH. Neither phentolamine (1 x 10-6 M), nor propranolol (1x I0-6 M), modified the histamine induced contraction of the estrogen primed guineapig uterus. Even reserpine pretreatment did not abolish responses to histamine. Our findings suggest the presence of both H1 and H2 receptors in the estrogen primed guineapig uterus. Both receptors appear to be excitatory and directly acting.






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