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Year : 1980  |  Volume : 12  |  Issue : 3  |  Page : 157-164

Effect of molindone pretreatment on apomorphine induced vasodepressor response, stereotypy and cage climbing behaviour:



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N V Nandal


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. Pretreatment with the neuroleptics viz, haloperidol and molindone significantly antagonised the vasodepressor response induced by apomorphine in anesthetized dogs. This vasodepressor response to apomorphine was, however, not significantly affected by atropine or propranolol pretreatment. Further, moliodone was also effective in antagonising apomorphine stereotypy in rats, apomorphine induced cage climbing behaviour in mice and apomorphine induced emesis in dogs. The results suggest that molindone is capable of blocking the peripheral dopamine receptors responsible for mediating apomorphine induced fall in blood pressure and also the central dopamine receptors responsible for mediating apomorphine induced stereotypy and emesis.






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