IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1035 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2949    
    Printed186    
    Emailed3    
    PDF Downloaded285    
    Comments [Add]    

Recommend this journal

 

 SHORT COMMUNICATION
Year : 1980  |  Volume : 12  |  Issue : 2  |  Page : 129-131

Safety of vasicine hydrochloride in human volunteers



Correspondence Address:
R L Wakhloo


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

. Pharmacological, animal toxicity, pharmacokinetic, formulation and stability studies carried out and reported from this Institute in recent years indicated that vasicine, the alkaloid of Adhotoda vasica holds promise for its use as an oxytocic/abortifacient in therapeutics. This report covers the investigations on its clinical pharmacology carried out on 24 human volunteers with 0.5-16 mg dose of vasicine injected iv. in 500 ml saline in 3 hours with the objective of determining any acute human toxicity, tolerance, pharmacological action, any untoward effect and safe dosage range. Vasicine tried upto 16 mg dose on the hospital in-patients on 2nd to 8th day of normal puerperium was well tolerated and showed no undesirable effect in clinical observations, haematological and biochemical investigations and kidney and liver function tests carried out before, during and after vasicine treatment. However, uterus became firm and contracted after vasicine treatment which indicated its effectiveness as an oxytocic.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow