| RESEARCH PAPER |
|
| Year : 1980 | Volume
: 12
| Issue : 1 | Page : 27-30 |
Effect of phenobarbitone pretreatment on tolbutamide half life in cases of hepatic cirrhosis
D Singh, R Vijayavargiya, P Mehta, AL Kakrani
,
Correspondence Address:
D Singh
.
One gram of sodium tolbutamide was administered orally to twenty-five patients with hepatic cirrhosis and five normal subjects and its serial plasma levels were measured both before and after phenobarbital pretreatment. Phenobarbital administration reduced the enhanced half life (t1/2) of tolbutamide in nonsmokers with hepatic cirrhosis but no significant alteration was produced in smokers with hepatic cirrhosis.
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