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 RESEARCH PAPER
Year : 1980  |  Volume : 12  |  Issue : 1  |  Page : 27-30

Effect of phenobarbitone pretreatment on tolbutamide half life in cases of hepatic cirrhosis


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D Singh


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. One gram of sodium tolbutamide was administered orally to twenty-five patients with hepatic cirrhosis and five normal subjects and its serial plasma levels were measured both before and after phenobarbital pretreatment. Phenobarbital administration reduced the enhanced half life (t1/2) of tolbutamide in nonsmokers with hepatic cirrhosis but no significant alteration was produced in smokers with hepatic cirrhosis.






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