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 RESEARCH PAPER
Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 277-281

Intracerebroventricular administration of histamine in conscious mice induces catalepsy



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M P Muley


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. Histamine (10-80 'g), when injected intracerebroventricularly in conscious mice, was found to induce dose dependent degree of catalepsy. Histamine-induced catalepsy was antagonised by chlorcyclizine, a H1-receptor blocker, while pretreatment with metiamide, a H2-receptor blocker, had no effect on histamine-induced catalepsy. The results indicate that the cataleptic effect of histamine is mediated through activation of H1 receptors.






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