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 RESEARCH PAPER
Year : 1979  |  Volume : 11  |  Issue : 4  |  Page : 241-248

Plasma fibrinolytic activity, fibrinogen level and platelet count in response to myocardial necrosis



Correspondence Address:
K K Saxena


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. The present study was carried out to investigate the changes in plasma fibrinolytic activity, fibrinogen level and platelet count in mongrel dogs and albino rats following myocardial damage. Dogs were subjected to coronary artery ligation to produce myocardial infarction. Myocardial necrosis in albino rats was produced by injecting isoprenaline (85.0 mg/kg s .c . for two days). In dogs as well as in rats myocardial necrosis was confirmed by histological examination of hearts. There was significant diminution of fibrinolytic activity as judged by prolonged euglobulin clotlysis time (ELT) and marked rise in plasma fibrinogen level in both the species of animals where myocardial necrois had set in. In another set of experiments on rats, graded myocardial necrosis was produced by injecting different doses of isoprenaline. Increase in ELT and plasma fibrinogen in these animals corresponded to the grades of necrosis. Suitability of plasma fibrinogen as an indicator of severity of myocardial damage is discussed.






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