| RESEARCH PAPER
|Year : 1979 | Volume
| Issue : 3 | Page : 201-208
Evidence for the indirect effect of histamine in the estrogen primed rat uterus
SC Verma, RK Goyal
Histamine and 4-methylhistamine (4-MH), a specific H2-receptor agonist produced dose related relaxation of uterine strips obtained from estrogen primed rats, while 2-(2-pyridyl) ethylamine (PEA), a specific H,-receptor agonist had no significant effect. Metiamide, the specific H2-receptor antagonist inhibited the responses to histamine and 4-MH, while mepyramine maleate, the specific H1- receptor antagonist did not produce any significant effect. Propranolol, the classical adrenergic beta-receptor antagonist also inhibited histamine and 4.MH induced relaxation of the estrogen primed rat uterus. Reserpine pretreatment (5 mg/kg) significantly reduced the histamine and 4-MH responses. Our findings suggest that histamine acts indirectly on the uterus to produce inhibition by stimulating H. receptors. H1-receptors do not appear to be present in the rat uterus.
S C Verma
Source of Support: None, Conflict of Interest: None