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 RESEARCH PAPER
Year : 1979  |  Volume : 11  |  Issue : 3  |  Page : 195-200

Study of histamine receptors in Guinea pig isolated seminal vesicle



Correspondence Address:
M S Naik


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. Histamine (l-4(g/ml), 4-methyl histamine (l00-400(g/ml), an H2-receptor agonist and 2-( 2-aminoethyl) pyridine (20-80 'g/ml), an H1-receptor agonist produced dose dependent contractions of the guineapig isolated seminal vesicle. Histamine responses were blocked partially by matiamide (1 'g/ml), an H2-antagonist and to a great extent by mepyramine (0.1 'g/ml) an H1-antagonist. Log dose response curves of histamine showed parallel shift to right in the presence of these antagonists. There was a delay in the initiation of histamine induced contraction in presence of metiamide. Mepyramine could block all the agonist responses effectively, whereas metiamide could block only the histamine and H2-agonist responses partially, the effect on H1-agonist responses being negligible. The results reveal the presence of both H1- and H2-receptors in guineapig seminal vesicle, both subserving a contractile response which is mostly mediated through H1-receptors, the H2-receptors playing only a minor role probably during the initiation of response.






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