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 RESEARCH PAPER
Year : 1979  |  Volume : 11  |  Issue : 2  |  Page : 107-111

Antihistaminic activity of 4’-fluoro-3-(1-piperidyl)propiophenon-a centrally acting skeletal muscle relaxant



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G K Patnaik


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. In concentration of 0.1-I(g/ml, compound 4-fluoro-3-(l-piperidyl) propiophenone produce+ dose dependent reversible inhibition of the spasmogenic effect of histamine on isolated guinea-pig ileum without altering its response to acetylcholine, 5 -hydroxytryptamine, incotine and KCI. On the isolated guineapig atria 2 (g/ml of the compound inhibited the positive chronotropic and inotropic effect of both histamine and adrenaline In doses of 2.5-10 mg/kg it reduced by about 80%, the hypotension induced by histamine but not that by acetylcholine or isopranalino in anaesthetised cat. The inhibitory effect lasted for 40.70 min. In the Konzett-Rossler preparation of guinea-pig, it (1mg/kg) blocked the broncho constriction induced by histamine without altering that by acetylcholine, It also protected the guineapigs from histamine induced bronchospasm as well as death due to intravenously administered histamine.






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