IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1979  |  Volume : 11  |  Issue : 2  |  Page : 101-105

Evidence for a neurogenic mechanism in dopamine induced depressor response in the anesthetized dog


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M F Lokhandwala


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. Intravenous administration of dopamine (0.5 to 8.0 'g/kg) to pentobarbital anesthetized dogs resulted in decreases in arterial blood pressure with no significant alterations in heart rate. This depressor action of dopamine was reversed into a pressor action after pretreatment with hexamethonium plus atropine. Dopamine again produced a depressor response in these animals after administration of phentolamine. Haloperidol pretreatment significantly attenuated this depressor effect of dopamine observed in ganglion blocked, phentolamine treated animals. These results demonstrate that the initial vasodepressor action of dopamine involves a neurogenic mechanism which may include activation of either the ganglionic and/or presynaptic dopamine receptors.






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