IPSIndian Journal of Pharmacology
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 SHORT COMMUNICATION
Year : 1978  |  Volume : 10  |  Issue : 4  |  Page : 319-322

A convenient method for evaluation of dermal irritant effect on rabbits



Correspondence Address:
R K Srivastava


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. A convenient method has been evolved to assess the dermal irritant effect of drugs and chemicals with low level of irritancy in conscious and unrestrained rabbits. Selected areas on either flank of rabbits were closely shaven and were painted with 20% formalin as primary irritant. Subsequently, pieces of cotton lint impregnated with the solutions of the test compounds encased in 'pill boxes' were placed in contact with the skin and 0.25 ml of a 0.5% sterile solution of Evans blue was injected intravenously. Intensity of blue colour developed in the treated areas was taken as the index of degree of dermal irritancy.






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