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 RESEARCH PAPER
Year : 1978  |  Volume : 10  |  Issue : 4  |  Page : 301-308

Pharmacokinetics of phenylbutazone in undernutrition



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C Adithan


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. Pharmacokinetics of phenylbutazone were studied in normal healthy volunteers and under-nourished patients. After a single oral dose of phenylbutazone, multiple venous blood samples were drawn and the concentrations of phenylbutazone in the plasma were determined as a function of time, and pharmacokinetic analysis was done. The mean plasma half-life was found to be significantly lower in undernourished subjects as compared to normal healthy volunteers. Both mean apparent volume of distribution (aVd/kg) and mean metabolic clearance rate were found to be significantly higher in the undernourished group which are indicative of increased extravascular distribution as well as more rapid hepatic metabolism in them. The area under curve was also found to be significantly reduced in them. Our results suggest that undernourished subjects may require administration of phenylbutazone at more frequent intervals.






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