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 RESEARCH PAPER
Year : 1978  |  Volume : 10  |  Issue : 4  |  Page : 277-293

Anti-inflammatory activity of gossypin of bioflavonoid isolated from Hibiscus vitifolius Linn



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N S Parmar


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. The anti-inflammatory activity of gossypin has been studied in comparison with the standard nonsteroid anti-inflammatory agent phenylbutazone against various experimental models of inflammation and increased vascular permeability. It was found to significantly reduce the rat paw , oedema and the increased vascular permeability induced by various phlogistic agents. It produced significant inhibition of the accumulation of pouch fluid and granulation tissue formation in the carrageenin induced granuloma pouch in rats which could be attributed to the decreased formation of collagen tissue. The migration of leucocytes and the formation of pleural exudates were also significantly reduced after pretreatment with gossypin in carrageenin and turpentine induced pleurisy in rats. It was also found effective against the adjuvant and formalin induced chronic arthritis in rats. Though it was less potent as compared to pheoylbutazone, it possessed a greater margin of safety as evident from the acute toxicity studies






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